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Target
Adenosylhomocysteinase
Ligand
BDBM50280301
Substrate
n/a
Meas. Tech.
ChEBML_196564
Ki
2400±n/a nM
Citation
 Jarvi, ET; McCarthy, JR; Mehdi, S; Matthews, DP; Edwards, ML; Prakash, NJ; Bowlin, TL; Sunkara, PS; Bey, P 4',5'-unsaturated 5'-halogenated nucleosides. Mechanism-based and competitive inhibitors of S-adenosyl-L-homocysteine hydrolase. J Med Chem 34:647-56 (1991) [PubMed]  Article 
Target
Name:
Adenosylhomocysteinase
Synonyms:
Adenosylhomocysteinase | Ahcy | SAHH_RAT
Type:
PROTEIN
Mol. Mass.:
47537.52
Organism:
Rattus norvegicus
Description:
ChEMBL_1507790
Residue:
432
Sequence:
MADKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY
  
Inhibitor
Name:
BDBM50280301
Synonyms:
(2R,3R,4S)-2-(6-Amino-purin-9-yl)-5-[1-fluoro-meth-(E)-ylidene]-tetrahydro-furan-3,4-diol | CHEMBL297437
Type:
Small organic molecule
Emp. Form.:
C10H10FN5O3
Mol. Mass.:
267.2165
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O\C(=C\F)[C@@H](O)[C@H]1O
Structure:
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