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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50041276
Substrate
n/a
Meas. Tech.
ChEMBL_201270 (CHEMBL804959)
Ki
6.6±n/a nM
Citation
 Glennon, RA; Smith, JD; Ismaiel, AM; el-Ashmawy, M; Battaglia, G; Fischer, JB Identification and exploitation of the sigma-opiate pharmacophore. J Med Chem 34:1094-8 (1991) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50041276
Synonyms:
CHEMBL20302 | Methyl-((S)-1-methyl-2-phenyl-ethyl)-phenethyl-amine
Type:
Small organic molecule
Emp. Form.:
C18H23N
Mol. Mass.:
253.3819
SMILES:
C[C@@H](Cc1ccccc1)N(C)CCc1ccccc1
Structure:
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