Target
Acyl-protein thioesterase 1
Ligand
BDBM50011926
Substrate
n/a
Meas. Tech.
ChEBML_100186
IC50
79000±n/a nM
Citation
 Van Schepdael, ABusson, RVanderhaeghe, HJClaes, PJVerbist, LMingeot-Leclercq, MPBrasseur, RTulkens, PM New derivatives of kanamycin B obtained by combined modifications in positions 1 and 6". Synthesis, microbiological properties, and in vitro and computer-aided toxicological evaluation. J Med Chem 34:1483-92 (1991) [PubMed]  Article 
Target
Name:
Acyl-protein thioesterase 1
Synonyms:
Acyl-protein thioesterase 1/2 | Apt1 | LYPA1_RAT | Lypla1 | Lysosomal phospholipase A1
Type:
PROTEIN
Mol. Mass.:
24708.49
Organism:
Rattus norvegicus
Description:
ChEMBL_12731
Residue:
230
Sequence:
MCGNNMSAPMPAVVPAARKATAAVIFLHGLGDTGHGWAEAFAGIKSSHIKYICPHAPVMPVTLNMSMMMPSWFDIIGLSPDSQEDESGIKQAAETVKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFSQGPINSANRDISVLQCHGDCDPLVPLMFGSLTVERLKGLVNPANVTFKVYEGMMHSSCQQEMMDVKYFIDKLLPPID
  
Inhibitor
Name:
BDBM50011926
Synonyms:
4-amino-2-[2,4-diamino-5-(3-amino-6-aminomethyl-4,5-dihydroxytetrahydro-2H-2-pyranyloxy)-6-hydroxy-2-hydroxymethylcyclohexyloxy]-6-hydroxymethyltetrahydro-2H-3,5-pyrandiol | CHEMBL38377
Type:
Small organic molecule
Emp. Form.:
C19H39N5O11
Mol. Mass.:
513.5399
SMILES:
NCC1OC(OC2C(N)CC(N)(CO)C(OC3OC(CO)C(O)C(N)C3O)C2O)C(N)C(O)C1O
Structure:
Search PDB for entries with ligand similarity: