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Target
Carbonic anhydrase 2
Ligand
BDBM50012207
Substrate
n/a
Meas. Tech.
ChEMBL_45238 (CHEMBL658941)
Ki
1.58±n/a nM
Citation
 Prugh, JD; Hartman, GD; Mallorga, PJ; McKeever, BM; Michelson, SR; Murcko, MA; Schwam, H; Smith, RL; Sondey, JM; Springer, JP New isomeric classes of topically active ocular hypotensive carbonic anhydrase inhibitors: 5-substituted thieno[2,3-b]thiophene-2-sulfonamides and 5-substituted thieno[3,2-b]thiophene-2-sulfonamides. J Med Chem 34:1805-18 (1991) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50012207
Synonyms:
5-{[[2-(2-Methoxy-ethoxy)-ethyl]-(2-methoxy-ethyl)-amino]-methyl}-thieno[2,3-b]thiophene-2-sulfonic acid amide; hydrochloride | CHEMBL543559
Type:
Small organic molecule
Emp. Form.:
C15H24N2O5S3
Mol. Mass.:
408.556
SMILES:
COCCOCCN(CCOC)Cc1cc2cc(sc2s1)S(N)(=O)=O
Structure:
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