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Target
Squalene synthase
Ligand
BDBM50059865
Substrate
n/a
Meas. Tech.
ChEMBL_202264 (CHEMBL813378)
Ki
10000±n/a nM
Citation
 Biller, SA; Forster, C; Gordon, EM; Harrity, T; Rich, LC; Marretta, J; Ciosek, CP Isoprenyl phosphinylformates: new inhibitors of squalene synthetase. J Med Chem 34:1912-4 (1991) [PubMed]  Article 
Target
Name:
Squalene synthase
Synonyms:
FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase
Type:
PROTEIN
Mol. Mass.:
48109.41
Organism:
Rattus norvegicus
Description:
ChEMBL_1336736
Residue:
416
Sequence:
MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQALDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRVVLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVGIGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYVKKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAKQLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
  
Inhibitor
Name:
BDBM50059865
Synonyms:
4,8,12-trimethyl-(3E,7E)-3,7,11-tridecatrienylhydroxyphosphorylmethylphosphonic acid anion | CHEMBL103617 | Farnesyl PMP, 2 | N-hydroxyglycine derivative | [Hydroxy-((3E,7E)-4,8,12-trimethyl-trideca-3,7,11-trienyl)-phosphinoylmethyl]-phosphonic acid | [Hydroxy-(4,8,12-trimethyl-trideca-3,7,11-trienyl)-phosphinoyl]-methanephosphonic acid anion | [Hydroxy-(4,8,12-trimethyl-trideca-3,7,11-trienyl)-phosphinoylmethyl]-phosphonate
Type:
Small organic molecule
Emp. Form.:
C17H32O5P2
Mol. Mass.:
378.3805
SMILES:
[#6]-[#6](-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6])-[#6]-[#6]=[#6]P([#8])(=O)[#6]P([#8])([#8])=O |w:14.13|
Structure:
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