Reaction Details Report a problem with these data
Target
72 kDa type IV collagenase
Ligand
BDBM50001017
Substrate
n/a
Meas. Tech.
ChEBML_49492
IC50
670±n/a nM
Citation
 Bols, M; Binderup, L; Hansen, J; Rasmussen, P Inhibition of collagenase by aranciamycin and aranciamycin derivatives. J Med Chem 35:2768-71 (1992) [PubMed]  Article 
Target
Name:
72 kDa type IV collagenase
Synonyms:
72 kDa gelatinase | 72 kDa type IV collagenase precursor | CLG4A | Gelatinase A | Gelatinase A (MMP-2) | MMP2 | MMP2_HUMAN | Matrix metalloproteinase-2 | Matrix metalloproteinase-2 (MMP 2) | Matrix metalloproteinase-2 (MMP2) | Matrix metalloproteinases 2 (MMP-2) | TBE-1
Type:
Enzyme
Mol. Mass.:
73870.36
Organism:
Homo sapiens (Human)
Description:
P08253
Residue:
660
Sequence:
MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
  
Inhibitor
Name:
BDBM50001017
Synonyms:
2,5,7-Trihydroxy-3-methoxy-2-methyl-4-(3,4,5-trimethoxy-6-methyl-tetrahydro-pyran-2-yloxy)-3,4-dihydro-2H-naphthacene-1,6,11-trione | CHEMBL328045
Type:
Small organic molecule
Emp. Form.:
C29H32O12
Mol. Mass.:
572.5572
SMILES:
COC1C(C)OC(O[C@H]2[C@H](OC)[C@](C)(O)C(=O)c3cc4C(=O)c5cccc(O)c5C(=O)c4c(O)c23)C(OC)C1OC
Structure:
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