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Target
Delta-type opioid receptor
Ligand
BDBM50001091
Substrate
n/a
Meas. Tech.
ChEMBL_147048 (CHEMBL753275)
Ki
91±n/a nM
Citation
 Chandrakumar, NS; Stapelfeld, A; Beardsley, PM; Lopez, OT; Drury, B; Anthony, E; Savage, MA; Williamson, LN; Reichman, M Analogs of the delta opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions. J Med Chem 35:2928-38 (1992) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | OPRD_RAT | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Opioid receptors; mu & delta | Oprd1 | Ror-a | Voltage-gated potassium channel
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40465.04
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor.
Residue:
372
Sequence:
MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50001091
Synonyms:
10-[2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propionylamino]-2-benzyl-6,6,9,9-tetramethyl-3,11-dioxo-1-oxa-7,8-dithia-4,12-diaza-cyclotetradecane-5-carboxylic acid methyl ester; hydrochloride | CHEMBL538514
Type:
Small organic molecule
Emp. Form.:
C33H46N4O7S2
Mol. Mass.:
674.871
SMILES:
COC(=O)[C@H]1NC(=O)C(Cc2ccccc2)OCCNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2c(C)cc(O)cc2C)C(C)(C)SSC1(C)C
Structure:
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