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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50019742
Substrate
n/a
Meas. Tech.
ChEMBL_226548 (CHEMBL846625)
IC50
1400±n/a nM
Citation
 Kimes, AS; Wilson, AA; Scheffel, U; Campbell, BG; London, ED Radiosynthesis, cerebral distribution, and binding of [125I]-1-(p-iodophenyl)-3-(1-adamantyl)guanidine, a ligand for sigma binding sites. J Med Chem 35:4683-9 (1993) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50019742
Synonyms:
9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9H-carbazole | 9-(3-(3,5-dimethylpiperazin-1-yl)propyl)-9H-carbazole | 9-[3-((3R,5R)-3,5-Dimethyl-piperazin-1-yl)-propyl]-9H-carbazole | 9-[3-((3R,5S)-3,5-Dimethyl-piperazin-1-yl)-propyl]-9H-carbazole | 9-[3-((3S,5R)-3,5-Dimethyl-piperazin-1-yl)-propyl]-9H-carbazole | 9-[3-(3,5-Dimethyl-piperazin-1-yl)-propyl]-9H-carbazole | 9-[3-(3,5-Dimethyl-piperazin-1-yl)-propyl]-9H-carbazole (Rimcazole) (BW234U) | 9-[3-(3,5-Dimethyl-piperazin-1-yl)-propyl]-9H-carbazole(rimcazole) | CHEMBL275707 | RIMCAZOLE
Type:
Small organic molecule
Emp. Form.:
C21H27N3
Mol. Mass.:
321.4592
SMILES:
C[C@H]1CN(CCCn2c3ccccc3c3ccccc23)C[C@@H](C)N1 |r|
Structure:
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