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Target
Transmembrane prolyl 4-hydroxylase
Ligand
BDBM50000400
Substrate
n/a
Meas. Tech.
ChEBML_157456
IC50
3000±n/a nM
Citation
 Dowell, RI; Hadley, EM Novel inhibitors of prolyl 4-hydroxylase. J Med Chem 35:800-4 (1992) [PubMed]  Article 
Target
Name:
Transmembrane prolyl 4-hydroxylase
Synonyms:
Hypoxia-inducible factor prolyl 4-hydroxylase | Hypoxia-inducible factor prolyl hydroxylase | Hypoxia-inducible factor prolyl hydroxylase 4 | Hypoxia-inducible factor prolyl hydroxylase 4 (HIF) | P4HTM | P4HTM_HUMAN | PH4 | Transmembrane prolyl 4-hydroxylase
Type:
Enzyme
Mol. Mass.:
56654.25
Organism:
Homo sapiens (Human)
Description:
Q9NXG6
Residue:
502
Sequence:
MAAAAVTGQRPETAAAEEASRPQWAPPDHCQAQAAAGLGDGEDAPVRPLCKPRGICSRAYFLVLMVFVHLYLGNVLALLLFVHYSNGDESSDPGPQHRAQGPGPEPTLGPLTRLEGIKVGHERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYEEAMSTMQVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREGGTDSQPEWALDRAYRDARVEL
  
Inhibitor
Name:
BDBM50000400
Synonyms:
5-Phenylmethanesulfonylaminocarbonyl-pyridine-2-carboxylic acid | CHEMBL355500
Type:
Small organic molecule
Emp. Form.:
C14H12N2O5S
Mol. Mass.:
320.32
SMILES:
OC(=O)c1ccc(cn1)C(=O)NS(=O)(=O)Cc1ccccc1
Structure:
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