Reaction Details Report a problem with these data
Target
Glutamate dehydrogenase 1, mitochondrial
Ligand
BDBM50368629
Substrate
n/a
Meas. Tech.
ChEBML_71837
Ki
15000±n/a nM
Citation
 Pankiewicz, KW; Zeidler, J; Ciszewski, LA; Bell, JE; Goldstein, BM; Jayaram, HN; Watanabe, KA Synthesis of isosteric analogues of nicotinamide adenine dinucleotide containing C-nucleotide of nicotinamide or picolinamide. J Med Chem 36:1855-9 (1993) [PubMed]  Article 
Target
Name:
Glutamate dehydrogenase 1, mitochondrial
Synonyms:
DHE3_BOVIN | GLUD | GLUD1 | Glutamate dehydrogenase
Type:
PROTEIN
Mol. Mass.:
61518.81
Organism:
Bos taurus
Description:
ChEMBL_71835
Residue:
558
Sequence:
MYRYLGEALLLSRAGPAALGSASADSAALLGWARGQPAAAPQPGLVPPARRHYSEAAADREDDPNFFKMVEGFFDRGASIVEDKLVEDLKTRETEEQKRNRVRSILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGVDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCITVGESDGSIWNPDGIDPKELEDFKLQHGTILGFPKAKIYEGSILEVDCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLNNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFRVYNEAGVTFT
  
Inhibitor
Name:
BDBM50368629
Synonyms:
CHEMBL2368671
Type:
Small organic molecule
Emp. Form.:
C21H27N7O14P2
Mol. Mass.:
663.4251
SMILES:
NC(=O)c1cncc(c1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](O)[C@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: