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Target
Endothelin-converting enzyme 1
Ligand
BDBM50407080
Substrate
n/a
Meas. Tech.
ChEMBL_64347 (CHEMBL676078)
IC50
3.1±n/a nM
Citation
 Shiosaki, K; Tasker, AS; Sullivan, GM; Sorensen, BK; von Geldern, TW; Wu-Wong, JR; Marselle, CA; Opgenorth, TJ Potent and selective inhibitors of an aspartyl protease-like endothelin converting enzyme identified in rat lung. J Med Chem 36:468-78 (1993) [PubMed]  Article 
Target
Name:
Endothelin-converting enzyme 1
Synonyms:
ECE1_RAT | ENDOTHELIN | Ece1 | Endothelin-converting enzyme 1 | Endothelin-converting enzyme 1 (ECE)
Type:
Protein
Mol. Mass.:
86126.89
Organism:
Rattus norvegicus (Rat)
Description:
P42893
Residue:
762
Sequence:
MGSLRPPQGLGLQWSSFFLGKKGPGLTVSLPLLASSLQVNFRSPRSGQRCWAARTSVEKRLVVLVTLLAAGLVACLAALGIQYRTRTPPVCLTEACVSVTSSILNSMDPTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASASEAEKKAQVYYRACMNETRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEDSIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNAIFYPVEINESEPIVVYDKEYLRQVSTLINSTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIASEIILEIKKAFEESLSTLKWMDEDTRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSLRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYNNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQILPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPLGSPMNPRHKCEVW
  
Inhibitor
Name:
BDBM50407080
Synonyms:
CHEMBL2112254
Type:
Small organic molecule
Emp. Form.:
C38H59N3O6
Mol. Mass.:
653.8916
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccc2ccccc2c1)[C@@H](O)[C@@H](O)CC(C)C
Structure:
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