Reaction Details Report a problem with these data
Target
Platelet-activating factor receptor
Ligand
BDBM50046966
Substrate
n/a
Meas. Tech.
ChEMBL_151700 (CHEMBL760449)
EC50
700±n/a nM
Citation
 Lamouri, A; Heymans, F; Tavet, F; Dive, G; Batt, JP; Blavet, N; Braquet, P; Godfroid, JJ Design and modeling of new platelet-activating factor antagonists. 1. Synthesis and biological activity of 1,4-bis(3',4',5'-trimethoxybenzoyl)-2-[[(substituted carbonyl and carbamoyl)oxy]methyl]piperazines. J Med Chem 36:990-1000 (1993) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Protein
Mol. Mass.:
39005.63
Organism:
Cavia porcellus
Description:
n/a
Residue:
342
Sequence:
MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
  
Inhibitor
Name:
BDBM50046966
Synonyms:
2-(N-butylaminocarbonyloxymethyl)-1,4-bis(3,4,5-trimethoxybenzoyl)piperazine | Butyl-carbamic acid 1,4-bis-(3,4,5-trimethoxy-benzoyl)-piperazin-2-ylmethyl ester | CHEMBL269340
Type:
Small organic molecule
Emp. Form.:
C30H41N3O10
Mol. Mass.:
603.6606
SMILES:
CCCCNC(=O)OCC1CN(CCN1C(=O)c1cc(OC)c(OC)c(OC)c1)C(=O)c1cc(OC)c(OC)c(OC)c1
Structure:
Search PDB for entries with ligand similarity: