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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50036852
Substrate
n/a
Meas. Tech.
ChEMBL_2107 (CHEMBL617142)
IC50
10000±n/a nM
Citation
 Podona, T; Guardiola-Lemaître, B; Caignard, DH; Adam, G; Pfeiffer, B; Renard, P; Guillaumet, G 3,4-Dihydro-3-amino-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 1. Synthesis and structure--activity relationship studies. J Med Chem 37:1779-93 (1994) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT2A | 5HT2A_BOVIN | 5HTR2A | HTR2A | Serotonin 2a (5-HT2a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52578.24
Organism:
BOVINE
Description:
5-HT2A HTR2A BOVINE::Q75Z89
Residue:
470
Sequence:
MDILCEENTSLSSTTNSLMQLHADTRLYSTDFNSGEGNTSNAFNWTVDSENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSTLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADENFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDPGTRTKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNRDVIEALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGPKKNSKKDDKTTDNDCTMVALGKEHPEDAPADSSNTVNEKVSCV
  
Inhibitor
Name:
BDBM50036852
Synonyms:
2-{4-[(5-Methoxy-chroman-3-yl)-propyl-amino]-butyl}-tetrahydro-cyclopenta[c]pyrrole-1,3-dione; compound with oxalic acid | CHEMBL50530
Type:
Small organic molecule
Emp. Form.:
C24H34N2O4
Mol. Mass.:
414.5378
SMILES:
CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1
Structure:
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