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Target
Thromboxane-A synthase
Ligand
BDBM50037039
Substrate
n/a
Meas. Tech.
ChEMBL_177767 (CHEMBL785227)
IC50
2±n/a nM
Citation
 Hibi, S; Okamoto, Y; Tagami, K; Numata, H; Kobayashi, N; Shinoda, M; Kawahara, T; Murakami, M; Oketani, K; Inoue, T Novel dual inhibitors of 5-lipoxygenase and thromboxane A2 synthetase: synthesis and structure-activity relationships of 3-pyridylmethyl-substituted 2-amino-6-hydroxybenzothiazole derivatives. J Med Chem 37:3062-70 (1994) [PubMed]  Article 
Target
Name:
Thromboxane-A synthase
Synonyms:
Cyp5 | Cyp5a1 | Cytochrome P450 5A1 | THAS_RAT | TXA synthase | TXS | Tbxas1
Type:
PROTEIN
Mol. Mass.:
59971.80
Organism:
Rattus norvegicus
Description:
ChEMBL_209768
Residue:
533
Sequence:
MEVLGLLKFEVSGTVVTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFRQGFWESHLELRERYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGLEPKLIADSVLMLRDRRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQRCYCCFTTNVVASVAFGIEVNSQDAPEDPFVQHCQRVFAFSTPRPLLALILSFPSIMVPLARILPNKNRDELNGFFNTLIRNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMVTEALSSAECMGDPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKHPAPEYCNLQEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEVLGQHIPAGSVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSALCPKNGVYVKIVSR
  
Inhibitor
Name:
BDBM50037039
Synonyms:
2-Amino-5,7-dimethyl-4-pyridin-3-ylmethyl-benzothiazol-6-ol; dihydrochloride | CHEMBL541579
Type:
Small organic molecule
Emp. Form.:
C15H15N3OS
Mol. Mass.:
285.364
SMILES:
Cc1c(O)c(C)c2sc(N)nc2c1Cc1cccnc1
Structure:
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