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Target5α-Reductase 1 (5α-R1)
LigandBDBM50037913
Substrate/Competitorn/a
Meas. Tech.ChEMBL_205213
IC50 2.7±n/a nM
Citation Bakshi, RKPatel, GFRasmusson, GHBaginsky, WFCimis, GEllsworth, KChang, BBull, HTolman, RLHarris, GS 4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase. J Med Chem37:3871-4 (1994) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5α-Reductase 1 (5α-R1)
Name:Steroid 5-alpha-reductase
Synonyms:3-oxo-5-alpha-steroid 4-dehydrogenase 1 | S5AR | SR type 1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:Enzyme
Mol. Mass.:29472.80
Organism:Homo sapiens (Human)
Description:P18405
Residue:259
Sequence:
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
LRKFEEYPKFRKIIIPFLF
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  Blast E-value cutoff:
BDBM50037913
NameBDBM50037913
Synonyms:(4aR,6aR,10S)-7-(1,5-Dimethyl-hexyl)-10-ethyl-4a,6a-dimethyl-hexadecahydro-indeno[5,4-f]quinolin-2-one | CHEMBL340684
TypeSmall organic molecule
Emp. Form.C28H49NO
Mol. Mass.415.6948
SMILESCC[C@H]1CC2NC(=O)CC[C@]2(C)C2CC[C@]3(C)C(CCC3C12)C(C)CCCC(C)C
Structure
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