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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM50037915
Substrate
n/a
Meas. Tech.
ChEMBL_205213 (CHEMBL816487)
IC50
5.7±n/a nM
Citation
 Bakshi, RK; Patel, GF; Rasmusson, GH; Baginsky, WF; Cimis, G; Ellsworth, K; Chang, B; Bull, H; Tolman, RL; Harris, GS 4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase. J Med Chem 37:3871-4 (1994) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:
Enzyme
Mol. Mass.:
29472.80
Organism:
Homo sapiens (Human)
Description:
P18405
Residue:
259
Sequence:
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
  
Inhibitor
Name:
BDBM50037915
Synonyms:
(4aR,6aR,10S)-7-(1,5-Dimethyl-hexyl)-10-ethyl-1,4a,6a-trimethyl-hexadecahydro-indeno[5,4-f]quinolin-2-one | CHEMBL127702
Type:
Small organic molecule
Emp. Form.:
C29H51NO
Mol. Mass.:
429.7213
SMILES:
CC[C@H]1CC2N(C)C(=O)CC[C@]2(C)C2CC[C@]3(C)C(CCC3C12)C(C)CCCC(C)C
Structure:
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