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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM50037920
Substrate
n/a
Meas. Tech.
ChEMBL_205213 (CHEMBL816487)
IC50
2.6±n/a nM
Citation
 Bakshi, RK; Patel, GF; Rasmusson, GH; Baginsky, WF; Cimis, G; Ellsworth, K; Chang, B; Bull, H; Tolman, RL; Harris, GS 4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase. J Med Chem 37:3871-4 (1994) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:
Enzyme
Mol. Mass.:
29472.80
Organism:
Homo sapiens (Human)
Description:
P18405
Residue:
259
Sequence:
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
  
Inhibitor
Name:
BDBM50037920
Synonyms:
(4aR,6aR,10S)-7-(1,5-Dimethyl-hexyl)-4a,6a,10-trimethyl-hexadecahydro-indeno[5,4-f]quinolin-2-one | CHEMBL340715
Type:
Small organic molecule
Emp. Form.:
C27H47NO
Mol. Mass.:
401.6682
SMILES:
CC(C)CCCC(C)C1CCC2C3[C@@H](C)CC4NC(=O)CC[C@]4(C)C3CC[C@]12C
Structure:
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