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Target
Kynurenine 3-monooxygenase
Ligand
BDBM50061907
Substrate
n/a
Meas. Tech.
ChEMBL_91744 (CHEMBL702205)
IC50
900±n/a nM
Citation
 Pellicciari, R; Natalini, B; Costantino, G; Mahmoud, MR; Mattoli, L; Sadeghpour, BM; Moroni, F; Chiarugi, A; Carpenedo, R Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoyl)alanine, a potent inhibitor of kynurenine-3-hydroxylase. J Med Chem 37:647-55 (1994) [PubMed]  Article 
Target
Name:
Kynurenine 3-monooxygenase
Synonyms:
KMO_RAT | Kmo
Type:
PROTEIN
Mol. Mass.:
54371.88
Organism:
Rattus norvegicus
Description:
ChEMBL_1487468
Residue:
478
Sequence:
MASSDTEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVANFMRGRSINLALSYRGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLTAVESYPNAKVHFGHKLSKCCPEEGILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKKPRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMSFEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLVAIGSAYILVHHLSPRPLELLRSAWTGTSGHWNRSADISPRVPWSH
  
Inhibitor
Name:
BDBM50061907
Synonyms:
(+/-)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric acid[(+/-)-m-nicotinylbenzoylalanine] | 2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric acid | CHEMBL23983 | meta-nitrobenzoyl)alanine
Type:
Small organic molecule
Emp. Form.:
C10H10N2O5
Mol. Mass.:
238.1968
SMILES:
NC(CC(=O)c1cccc(c1)[N+]([O-])=O)C(O)=O
Structure:
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