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Target5α-Reductase 1 (5α-R1)
LigandBDBM50407405
Substrate/Competitorn/a
Meas. Tech.ChEMBL_204883
Ki 0.200000±n/a nM
Citation Frye, SVHaffner, CDMaloney, PRHiner, RNDorsey, GFNoe, RAUnwalla, RJBatchelor, KWBramson, HNStuart, JD Structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase by 6-azaandrost-4-en-3-ones: optimization of the C17 substituent. J Med Chem38:2621-7 (1995) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5α-Reductase 1 (5α-R1)
Name:Steroid 5-alpha-reductase
Synonyms:3-oxo-5-alpha-steroid 4-dehydrogenase 1 | S5AR | SR type 1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:Enzyme
Mol. Mass.:29472.80
Organism:Homo sapiens (Human)
Description:P18405
Residue:259
Sequence:
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
LRKFEEYPKFRKIIIPFLF
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  Blast E-value cutoff:
BDBM50407405
NameBDBM50407405
Synonyms:CHEMBL2115222
TypeSmall organic molecule
Emp. Form.C27H29ClF6N2O2
Mol. Mass.562.975
SMILESC[C@]12CC[C@H]3[C@@H](CN=C4C(Cl)C(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)Nc1c(cccc1C(F)(F)F)C(F)(F)F |t:7|
Structure
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