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TargetSteroid 5-alpha-reductase
LigandBDBM50031877
Substrate/Competitorn/a
Meas. Tech.ChEMBL_204891
Ki 0.10±n/a nM
Citation Frye, SVHaffner, CDMaloney, PRHiner, RNDorsey, GFNoe, RAUnwalla, RJBatchelor, KWBramson, HNStuart, JD Structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase by 6-azaandrost-4-en-3-ones: optimization of the C17 substituent. J Med Chem38:2621-7 (1995) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Steroid 5-alpha-reductase
Name:Steroid 5-alpha-reductase
Synonyms:Steroid 5-alpha-reductase 1
Type:PROTEIN
Mol. Mass.:29788.29
Organism:Rattus norvegicus
Description:ChEMBL_1441437
Residue:259
Sequence:
MVPLMELDELCLLDMLVYLEGFMAFVSIVGLRSVGSPYGRYSPQWPGIRVPARPAWFIQE
LPSMAWPLYEYIRPAAARLGNLPNRVLLAMFLIHYVQRTLVFPVLIRGGKPTLLVTFVLA
FLFCTFNGYVQSRYLSQFAVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGE
TGYKIPRGGLFEYVSAANYFGELVEWCGFALASWSLQGVVFALFTLSTLLTRAKQHHQWY
HEKFEDYPKSRKILIPFVL
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  Blast E-value cutoff:
BDBM50031877
NameBDBM50031877
Synonyms:(1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid (2-tert-butyl-5-trifluoromethyl-phenyl)-amide | CHEMBL277224
TypeSmall organic molecule
Emp. Form.C30H39F3N2O2
Mol. Mass.516.6381
SMILESCC(C)(C)c1ccc(cc1NC(=O)[C@H]1CCC2C3CN=C4CC(=O)CC[C@]4(C)C3CC[C@]12C)C(F)(F)F |t:20|
Structure
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