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Target
Spermidine synthase
Ligand
BDBM50095449
Substrate
n/a
Meas. Tech.
ChEMBL_160084 (CHEMBL768669)
IC50
>10000±n/a nM
Citation
 Lakanen, JR; Pegg, AE; Coward, JK Synthesis and biochemical evaluation of adenosylspermidine, a nucleoside-polyamine adduct inhibitor of spermidine synthase. J Med Chem 38:2714-27 (1995) [PubMed]  Article 
Target
Name:
Spermidine synthase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
33991.53
Organism:
Rattus norvegicus
Description:
ChEMBL_201181
Residue:
302
Sequence:
MEPGPDGPAAPGPAAIREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFRSKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDGGVLREVVKHPSVESVVQCEIDEDVIEVSKKFLPGMAVGYSSSKLTLHVGDGFEFMKQNQDAFDVIITDSSDPMGPAESLFKESYYQLMKTALKEDGILCCQGECQWLHLDLIKEMRHFCKSLFPVVSYAYCTIPTYPSGQIGFMLCSKNPSTNFREPVQQLTQAQVEQMQLKYYNSDMHRAAFVLPEFTRKALNDIS
  
Inhibitor
Name:
BDBM50095449
Synonyms:
2-[1-(2-Amino-ethyl)-6-(3-amino-propylamino)-hexylsulfanylmethyl]-5-(6-amino-purin-9-yl)-tetrahydro-furan-3,4-diol | CHEMBL315995
Type:
Small organic molecule
Emp. Form.:
C21H38N8O3S
Mol. Mass.:
482.643
SMILES:
NCCCNCCCCCC(CCN)SC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Structure:
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