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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50010686
Substrate
n/a
Meas. Tech.
ChEMBL_2240 (CHEMBL617185)
Ki
>3000±n/a nM
Citation
 Michaelides, MR; Hong, Y; DiDomenico, S; Asin, KE; Britton, DR; Lin, CW; Williams, M; Shiosaki, K (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diacetyl prodrug (ABT-431). J Med Chem 38:3445-7 (1995) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT2A | 5HT2A_BOVIN | 5HTR2A | HTR2A | Serotonin 2a (5-HT2a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52578.24
Organism:
BOVINE
Description:
5-HT2A HTR2A BOVINE::Q75Z89
Residue:
470
Sequence:
MDILCEENTSLSSTTNSLMQLHADTRLYSTDFNSGEGNTSNAFNWTVDSENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSTLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADENFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDPGTRTKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNRDVIEALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGPKKNSKKDDKTTDNDCTMVALGKEHPEDAPADSSNTVNEKVSCV
  
Inhibitor
Name:
BDBM50010686
Synonyms:
(6aR,12bS)-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydro-benzo[a]phenanthridinium | (6aR,12bS)-5,6,6a,7,8,12b-Hexahydro-benzo[a]phenanthridine-10,11-diol | 10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydro-benzo[a]phenanthridinium(DHX) | 5,6,6a,7,8,12b-Hexahydro-benzo[a]phenanthridine-10,11-diol | CHEMBL25856 | dihydrexidine
Type:
Small organic molecule
Emp. Form.:
C17H17NO2
Mol. Mass.:
267.3224
SMILES:
Oc1cc2CC[C@H]3NCc4ccccc4[C@@H]3c2cc1O
Structure:
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