Reaction Details Report a problem with these data
Target
Adenosylhomocysteinase
Ligand
BDBM50051435
Substrate
n/a
Meas. Tech.
ChEMBL_196742 (CHEMBL857626)
Ki
39±n/a nM
Citation
 Wnuk, SF; Liu, S; Yuan, CS; Borchardt, RT; Robins, MJ Inactivation of S-adenosyl-L-homocysteine hydrolase by amide and ester derivatives of adenosine-5'-carboxylic acid. J Med Chem 39:4162-6 (1996) [PubMed]  Article 
Target
Name:
Adenosylhomocysteinase
Synonyms:
AHCY | Adenosylhomocysteinase | SAHH | SAHH_HUMAN
Type:
PROTEIN
Mol. Mass.:
47714.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507791
Residue:
432
Sequence:
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY
  
Inhibitor
Name:
BDBM50051435
Synonyms:
5'-Dehydroadenosine | 5'-deoxy-5'-oxoadenosine | 9-beta-D-ribo-pentodialdo-1,4-furanosyl-9H-purin-6-amine | CHEMBL308037
Type:
Small organic molecule
Emp. Form.:
C10H11N5O4
Mol. Mass.:
265.2254
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](C=O)[C@@H](O)[C@H]1O
Structure:
Search PDB for entries with ligand similarity: