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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM50032281
Substrate
n/a
Meas. Tech.
ChEMBL_205199 (CHEMBL817369)
IC50
4100±n/a nM
Citation
 Takami, H; Koshimura, H; Kishibayashi, N; Ishii, A; Nonaka, H; Aoyama, S; Kase, H; Kumazawa, T Indole derivatives as a new class of steroid 5 alpha-reductase inhibitors. J Med Chem 39:5047-52 (1997) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
S5A1_RAT | Srd5a1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:
PROTEIN
Mol. Mass.:
29788.29
Organism:
Rattus norvegicus
Description:
ChEMBL_1441437
Residue:
259
Sequence:
MVPLMELDELCLLDMLVYLEGFMAFVSIVGLRSVGSPYGRYSPQWPGIRVPARPAWFIQELPSMAWPLYEYIRPAAARLGNLPNRVLLAMFLIHYVQRTLVFPVLIRGGKPTLLVTFVLAFLFCTFNGYVQSRYLSQFAVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGETGYKIPRGGLFEYVSAANYFGELVEWCGFALASWSLQGVVFALFTLSTLLTRAKQHHQWYHEKFEDYPKSRKILIPFVL
  
Inhibitor
Name:
BDBM50032281
Synonyms:
4-(2-{(E)-3-[1-(1-Propyl-pentyl)-1H-indol-5-yl]-but-2-enoylamino}-phenoxy)-butyric acid | CHEMBL99514
Type:
Small organic molecule
Emp. Form.:
C30H38N2O4
Mol. Mass.:
490.6337
SMILES:
CCCCC(CCC)n1ccc2cc(ccc12)C(\C)=C\C(=O)Nc1ccccc1OCCCC(O)=O
Structure:
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