Reaction Details Report a problem with these data
Target
Steryl-sulfatase
Ligand
BDBM50051829
Substrate
n/a
Meas. Tech.
ChEMBL_67990 (CHEMBL679546)
IC50
380±n/a nM
Citation
 Woo, LW; Purohit, A; Reed, MJ; Potter, BV Active site directed inhibition of estrone sulfatase by nonsteroidal coumarin sulfamates. J Med Chem 39:1349-51 (1996) [PubMed]  Article 
Target
Name:
Steryl-sulfatase
Synonyms:
ARSC1 | ASC | Arylsulfatase C | STS | STS_HUMAN | Steroid sulfatase | Steryl-sulfate sulfohydrolase
Type:
Enzyme
Mol. Mass.:
65503.66
Organism:
Homo sapiens (Human)
Description:
P08842
Residue:
583
Sequence:
MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR
  
Inhibitor
Name:
BDBM50051829
Synonyms:
4-methyl-2-oxo-2H-chromen-7-yl sulfamate | CHEMBL11185 | Sulfamic acid 4-methyl-2-oxo-2H-chromen-7-yl ester
Type:
Small organic molecule
Emp. Form.:
C10H9NO5S
Mol. Mass.:
255.247
SMILES:
Cc1cc(=O)oc2cc(OS(N)(=O)=O)ccc12
Structure:
Search PDB for entries with ligand similarity: