Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
Target3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
LigandBDBM50057504
Substrate/Competitorn/a
Meas. Tech.ChEMBL_328
IC50 8.3±n/a nM
Citation Kenny, BBallard, SBlagg, JFox, D Pharmacological options in the treatment of benign prostatic hyperplasia. J Med Chem40:1293-315 (1997) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
Name:3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
Synonyms:3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 | 3-beta-HSD I | 3-beta-hydroxy-5-ene steroid dehydrogenase | 3-beta-hydroxy-Delta(5)-steroid dehydrogenase | Delta-5-3-ketosteroid isomerase | Progesterone reductase | Trophoblast antigen FDO161G
Type:PROTEIN
Mol. Mass.:42261.17
Organism:Homo sapiens (Human)
Description:ChEMBL_329
Residue:373
Sequence:
MTGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFGPELREEFSKLQNKTKLTVLE
GDILDEPFLKRACQDVSVIIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVF
IYTSSIEVAGPNSYKEIIQNGHEEEPLENTWPAPYPHSKKLAEKAVLAANGWNLKNGGTL
YTCALRPMYIYGEGSRFLSASINEALNNNGILSSVGKFSTVNPVYVGNVAWAHILALRAL
QDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRLDSRWSFPLSLMYWIGFLLEI
VSFLLRPIYTYRPPFNRHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQKTVEWVGSL
VDRHKETLKSKTQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50057504
NameBDBM50057504
Synonyms:(1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid (3,3-dimethyl-butyl)-amide | CHEMBL24033
TypeSmall organic molecule
Emp. Form.C25H40N2O2
Mol. Mass.400.5973
SMILESCC(C)(C)CCNC(=O)[C@H]1CCC2C3CN=C4CC(=O)CC[C@]4(C)C3CC[C@]12C |t:15|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a