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Target
Pepsin A-5
Ligand
BDBM912
Substrate
n/a
Meas. Tech.
ChEMBL_154149 (CHEMBL759819)
IC50
59±n/a nM
Citation
 Kratzel, M; Hiessböck, R; Bernkop-Schnürch, A Auxiliary agents for the peroral administration of peptide and protein drugs: synthesis and evaluation of novel pepstatin analogues. J Med Chem 41:2339-44 (1998) [PubMed]  Article 
Target
Name:
Pepsin A-5
Synonyms:
PEPA5_HUMAN | PGA5 | Pepsin A | Pepsinogen A5
Type:
PROTEIN
Mol. Mass.:
41971.56
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1452206
Residue:
388
Sequence:
MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDKSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQITVDSITMNGETIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNVPTESGELWILGDVFIRQYFTVFDRANNQVGLAPVA
  
Inhibitor
Name:
BDBM912
Synonyms:
(3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-methyl-4-[(2S)-3-methyl-2-[(2S)-3-methyl-2-(3-methylbutanamido)butanamido]butanamido]heptanamido]propanamido]-6-methylheptanoic acid | CHEMBL296588 | Iva-Val-Val-Sta-Ala-Sta-OH | N-[(3-Methyl-1-oxobutyl)-L-valyl-L-valyl-4-amino-3-hydroxy-6-methylheptanoyl-L-alanyl]-4-amino-3-hydroxy-6-methylheptanoic acid | PEPSTATIN | Pepstatine | US9115083, Pepstatin
Type:
Small organic molecule
Emp. Form.:
C34H63N5O9
Mol. Mass.:
685.8921
SMILES:
CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CC(C)C)C(C)C)C(C)C)[C@@H](O)CC(O)=O |r|
Structure:
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