Reaction Details Report a problem with these data
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50066596
Substrate
n/a
Meas. Tech.
ChEMBL_52887 (CHEMBL665411)
IC50
>50000±n/a nM
Citation
 Papageorgiou, C; Albert, R; Floersheim, P; Lemaire, M; Bitch, F; Weber, HP; Andersen, E; Hungerford, V; Schreier, MH Pyrazole bioisosteres of leflunomide as B-cell immunosuppressants for xenotransplantation and chronic rejection: scope and limitations. J Med Chem 41:3530-8 (1998) [PubMed]  Article 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM50066596
Synonyms:
5-tert-Butyl-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile | CHEMBL118586
Type:
Small organic molecule
Emp. Form.:
C15H15F3N4
Mol. Mass.:
308.3016
SMILES:
CC(C)(C)c1n[nH]c(Nc2ccc(cc2)C(F)(F)F)c1C#N
Structure:
Search PDB for entries with ligand similarity: