Reaction Details Report a problem with these data
Target
B2 bradykinin receptor
Ligand
BDBM50067244
Substrate
n/a
Meas. Tech.
ChEMBL_40264 (CHEMBL653280)
IC50
4.2±n/a nM
Citation
 Abe, Y; Kayakiri, H; Satoh, S; Inoue, T; Sawada, Y; Inamura, N; Asano, M; Hatori, C; Sawai, H; Oku, T; Tanaka, H A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 2. Overcoming the species difference between guinea pig and man. J Med Chem 41:4053-61 (1998) [PubMed]  Article 
Target
Name:
B2 bradykinin receptor
Synonyms:
B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKRB2_CAVPO | Bradykinin B2 receptor
Type:
n/a
Mol. Mass.:
42217.03
Organism:
Cavia porcellus
Description:
n/a
Residue:
372
Sequence:
MFNITSQVSALNATLAQGNSCLDAEWWSWLNTIQAPFLWVLFVLAVLENIFVLSVFFLHKSSCTVAEIYLGNLAVADLILAFGLPFWAITIANNFDWLFGEVLCRMVNTMIQMNMYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCALLLSSPMLVFRTMKDYRDEGHNVTACLIIYPSLTWQVFTNVLLNLVGFLLPLSIITFCTVQIMQVLRNNEMQKFKEIQTERRATVLVLAVLLLFVVCWLPFQIGTFLDTLRLLGFLPGCWEHVIDLITQISSYLAYSNSCLNPLVYVIVGKRFRKKSREVYHGLCRSGGCVSEPAQSENSMGTLRTSISVDRQIHKLQDWARSSSEGTPPGLL
  
Inhibitor
Name:
BDBM50067244
Synonyms:
CHEMBL545765 | N-[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin-8-yloxymethyl)-2,4-dichloro-phenyl]-N-methyl-2-[3-(3-nitro-phenyl)-ureido]-acetamide; hydrochloride
Type:
Small organic molecule
Emp. Form.:
C25H21BrCl2N6O5
Mol. Mass.:
636.281
SMILES:
CN(C(=O)CNC(=O)Nc1cccc(c1)[N+]([O-])=O)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Structure:
Search PDB for entries with ligand similarity: