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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50067772
Substrate
n/a
Meas. Tech.
ChEMBL_61515 (CHEMBL671435)
IC50
0.146000±n/a nM
Citation
 Hoepping, A; Reisgys, M; Brust, P; Seifert, S; Spies, H; Alberto, R; Johannsen, B TROTEC-1: a new high-affinity ligand for labeling of the dopamine transporter. J Med Chem 41:4429-32 (1998) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3
Type:
Multi-pass membrane protein
Mol. Mass.:
68497.11
Organism:
Homo sapiens (Human)
Description:
Q01959
Residue:
620
Sequence:
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHWLKV
  
Inhibitor
Name:
BDBM50067772
Synonyms:
CHEMBL343369 | Rhenium complex of 3-(2-Bromo-2,2,2-triformyl-3-methyl-1lambda*4*,2lambda*6*,3lambda*4*-[1,2,3]dithiolan-1-yl)-propionic acid 3-(4-fluoro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-ylmethyl ester
Type:
Small organic molecule
Emp. Form.:
C24H33BrFNO5ReS2
Mol. Mass.:
764.761
SMILES:
CN1C2CCC1[C@@H](COC(=O)CC[S+]1CC[S+](C)[Re]1(Br)(C=O)(C=O)C=O)[C@H](C2)c1ccc(F)cc1 |TLB:28:26:1:4.3,7:6:1:4.3|
Structure:
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