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Target
B2 bradykinin receptor
Ligand
BDBM50062878
Substrate
n/a
Meas. Tech.
ChEMBL_40262 (CHEMBL653278)
IC50
8.9±n/a nM
Citation
 Abe, Y; Kayakiri, H; Satoh, S; Inoue, T; Sawada, Y; Imai, K; Inamura, N; Asano, M; Hatori, C; Katayama, A; Oku, T; Tanaka, H A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 1. Construction of the basic framework. J Med Chem 41:564-78 (1998) [PubMed]  Article 
Target
Name:
B2 bradykinin receptor
Synonyms:
B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKRB2_CAVPO | Bradykinin B2 receptor
Type:
n/a
Mol. Mass.:
42217.03
Organism:
Cavia porcellus
Description:
n/a
Residue:
372
Sequence:
MFNITSQVSALNATLAQGNSCLDAEWWSWLNTIQAPFLWVLFVLAVLENIFVLSVFFLHKSSCTVAEIYLGNLAVADLILAFGLPFWAITIANNFDWLFGEVLCRMVNTMIQMNMYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCALLLSSPMLVFRTMKDYRDEGHNVTACLIIYPSLTWQVFTNVLLNLVGFLLPLSIITFCTVQIMQVLRNNEMQKFKEIQTERRATVLVLAVLLLFVVCWLPFQIGTFLDTLRLLGFLPGCWEHVIDLITQISSYLAYSNSCLNPLVYVIVGKRFRKKSREVYHGLCRSGGCVSEPAQSENSMGTLRTSISVDRQIHKLQDWARSSSEGTPPGLL
  
Inhibitor
Name:
BDBM50062878
Synonyms:
CHEMBL131517 | N-({[3-(3-Bromo-2-methyl-imidazo[1,2-a]pyridin-8-yloxymethyl)-2,4-dichloro-phenyl]-methyl-carbamoyl}-methyl)-butyramide
Type:
Small organic molecule
Emp. Form.:
C22H23BrCl2N4O3
Mol. Mass.:
542.253
SMILES:
CCCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl
Structure:
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