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TargetSerotonin receptor 2a and 2c (5HT2A and 5HT2C)
LigandBDBM50451023
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2811
Ki 0.730000±n/a nM
Citation Cappelli, AAnzini, MVomero, SMennuni, LMakovec, FDoucet, EHamon, MBruni, GRomeo, MRMenziani, MCDe Benedetti, PGLanger, T Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives. J Med Chem41:728-41 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
Name:Serotonin (5-HT) receptor
Synonyms:5-HT2C | 5-hydroxytryptamine receptor 2C | 5-hydroxytryptamine receptor 2C (5HT2c) | HTR2C
Type:Enzyme
Mol. Mass.:51935.10
Organism:Rattus norvegicus (Rat)
Description:P08909
Residue:460
Sequence:
MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALS
IVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYV
WPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVW
AISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIY
VLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRG
TMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGY
VCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRH
TNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
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  Blast E-value cutoff:
BDBM50451023
NameBDBM50451023
Synonyms:MESULERGINE
TypeSmall organic molecule
Emp. Form.C19H28N4O2S
Mol. Mass.376.516
SMILES[H][C@@]12Cc3cn(C)c4cccc(c34)[C@@]1([H])C[C@H](CNS(=O)(=O)N(C)C)CN2C |r|
Structure
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