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Target
Ornithine transcarbamylase, mitochondrial
Ligand
BDBM50079021
Substrate
n/a
Meas. Tech.
ChEMBL_148266 (CHEMBL750183)
pH
6±n/a
Ki
>20000000±n/a nM
Comments
extracted
Citation
 Flohr, A; Aemissegger, A; Hilvert, D alpha-Functionalized phosphonylphosphinates: synthesis and evaluation as transcarbamoylase inhibitors. J Med Chem 42:2633-40 (1999) [PubMed]  Article 
Target
Name:
Ornithine transcarbamylase, mitochondrial
Synonyms:
OTC | OTC_HUMAN | Ornithine carbamoyltransferase
Type:
PROTEIN
Mol. Mass.:
39943.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_148264
Residue:
354
Sequence:
MLFNLRILLNNAAFRNGHNFMVRNFRCGQPLQNKVQLKGRDLLTLKNFTGEEIKYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLSTETGFALLGGHPCFLTTQDIHLGVNESLTDTARVLSSMADAVLARVYKQSDLDTLAKEASIPIINGLSDLYHPIQILADYLTLQEHYSSLKGLTLSWIGDGNNILHSIMMSAAKFGMHLQAATPKGYEPDASVTKLAEQYAKENGTKLLLTNDPLEAAHGGNVLITDTWISMGQEEEKKKRLQAFQGYQVTMKTAKVAASDWTFLHCLPRKPEEVDDEVFYSPRSLVFPEAENRKWTIMAVMVSLLTDYSPQLQKPKF
  
Inhibitor
Name:
BDBM50079021
Synonyms:
(2S)-2-[(tert-butoxycarbonyl)amino]-5-[({[(hydroxyphosphinato)methyl]phosphinato}methyl)ammonio]pentanoate
Type:
Small organic molecule
Emp. Form.:
C12H24N2O9P2
Mol. Mass.:
402.2756
SMILES:
CC(C)(C)OC(=O)N[C@@H](CCC[NH2+]CP([O-])(=O)CP(O)([O-])=O)C([O-])=O
Structure:
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