Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50080665
Substrate
n/a
Meas. Tech.
ChEMBL_45082 (CHEMBL657153)
Ki
23±n/a nM
Citation
 Scozzafava, A; Briganti, F; Mincione, G; Menabuoni, L; Mincione, F; Supuran, CT Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route. J Med Chem 42:3690-700 (1999) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50080665
Synonyms:
2-Amino-N-[4-(4-sulfamoyl-phenylamino)-pyrimidin-2-yl]-acetamide | CHEMBL122176
Type:
Small organic molecule
Emp. Form.:
C12H14N6O3S
Mol. Mass.:
322.343
SMILES:
NCC(=O)Nc1nccc(Nc2ccc(cc2)S(N)(=O)=O)n1
Structure:
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