Reaction Details Report a problem with these data
Target
Carbonic anhydrase 4
Ligand
BDBM50080730
Substrate
n/a
Meas. Tech.
ChEMBL_45427 (CHEMBL657028)
Ki
39±n/a nM
Citation
 Scozzafava, A; Briganti, F; Mincione, G; Menabuoni, L; Mincione, F; Supuran, CT Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route. J Med Chem 42:3690-700 (1999) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 4
Synonyms:
CA-IV | CA4 | CAH4_BOVIN | Carbonate dehydratase IV | Carbonic Anhydrase IV | Carbonic anhydrase | Carbonic anhydrase 4
Type:
Enzyme
Mol. Mass.:
35152.74
Organism:
Bos taurus (bovine)
Description:
Bovine isozyme, isolated from lung microsomes
Residue:
312
Sequence:
MRLLLALLVLAAAPPQARAASHWCYQIQVKPSNYTCLEPDEWEGSCQNNRQSPVNIVTAKTQLDPNLGRFSFSGYNMKHQWVVQNNGHTVMVLLENKPSIAGGGLSTRYQATQLHLHWSRAMDRGSEHSFDGERFAMEMHIVHEKEKGLSGNASQNQFAEDEIAVLAFMVEDGSKNVNFQPLVEALSDIPRPNMNTTMKEGVSLFDLLPEEESLRHYFRYLGSLTTPTCDEKVVWTVFQKPIQLHRDQILAFSQKLFYDDQQKVNMTDNVRPVQSLGQRQVFRSGAPGLLLAQPLPTLLAPVLACLTVGFLR
  
Inhibitor
Name:
BDBM50080730
Synonyms:
2-Methylamino-N-(5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-acetamide | CHEMBL122951
Type:
Small organic molecule
Emp. Form.:
C5H9N5O3S2
Mol. Mass.:
251.287
SMILES:
CNCC(=O)Nc1nnc(s1)S(N)(=O)=O
Structure:
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