Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 1
Ligand
BDBM50082723
Substrate
n/a
Meas. Tech.
ChEMBL_41751 (CHEMBL651702)
Ki
93±n/a nM
Citation
 Ng, HP; May, K; Bauman, JG; Ghannam, A; Islam, I; Liang, M; Horuk, R; Hesselgesser, J; Snider, RM; Perez, HD; Morrissey, MM Discovery of novel non-peptide CCR1 receptor antagonists. J Med Chem 42:4680-94 (1999) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 1
Synonyms:
C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1
Type:
Enzyme
Mol. Mass.:
41180.69
Organism:
Homo sapiens (Human)
Description:
P32246
Residue:
355
Sequence:
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
  
Inhibitor
Name:
BDBM50082723
Synonyms:
5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-ethyl-2-phenyl-pentanenitrile | CHEMBL343028
Type:
Small organic molecule
Emp. Form.:
C24H29ClN2O
Mol. Mass.:
396.953
SMILES:
CCC(CCCN1CCC(O)(CC1)c1ccc(Cl)cc1)(C#N)c1ccccc1
Structure:
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