Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50083268
Substrate
n/a
Meas. Tech.
ChEMBL_63032 (CHEMBL678335)
Ki
14±n/a nM
Citation
Abou-Gharbia, MA; Childers, WE; Fletcher, H; McGaughey, G; Patel, U; Webb, MB; Yardley, J; Andree, T; Boast, C; Kucharik, RJ; Marquis, K; Morris, H; Scerni, R; Moyer, JA Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents. J Med Chem 42:5077-94 (2000) [PubMed] Article
More Info.:
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
Inhibitor
Name:
BDBM50083268
Synonyms:
Adamantane-1-carboxylic acid 2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl ester; Dihydrochloride | CHEMBL542983
Type:
Small organic molecule
Emp. Form.:
C24H34N2O3
Mol. Mass.:
398.5384
SMILES:
COc1ccccc1N1CCN(CCOC(=O)C23C[C@H]4C[C@H](C[C@H](C4)C2)C3)CC1 |TLB:24:23:26:18.19.20,24:19:26:25.23.22|