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Target
D(4) dopamine receptor
Ligand
BDBM50083337
Substrate
n/a
Meas. Tech.
ChEMBL_63106 (CHEMBL674499)
Ki
2.6±n/a nM
Citation
 Belliotti, TR; Wustrow, DJ; Brink, WA; Zoski, KT; Shih, YH; Whetzel, SZ; Georgic, LM; Corbin, AE; Akunne, HC; Heffner, TG; Pugsley, TA; Wise, LD A series of 6- and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: discovery of a potential atypical antipsychotic agent. J Med Chem 42:5181-7 (2000) [PubMed]  Article 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50083337
Synonyms:
7-[4-(3,4-Dimethyl-phenyl)-piperidin-1-ylmethyl]-4H-benzo[1,4]oxazin-3-one | CHEMBL147059
Type:
Small organic molecule
Emp. Form.:
C22H26N2O2
Mol. Mass.:
350.454
SMILES:
Cc1ccc(cc1C)C1CCN(Cc2ccc3NC(=O)COc3c2)CC1
Structure:
Search PDB for entries with ligand similarity: