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Target
Renin
Ligand
BDBM50084618
Substrate
n/a
Meas. Tech.
ChEMBL_196433 (CHEMBL878013)
IC50
7.1±n/a nM
Citation
 Leung, D; Abbenante, G; Fairlie, DP Protease inhibitors: current status and future prospects. J Med Chem 43:305-41 (2000) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50084618
Synonyms:
5-{2-[3-Benzyl-4-(4-methyl-piperazine-1-carbonyl)-2-oxo-piperazin-1-yl]-hexanoylamino}-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid propylamide(pepstatin(A-70450)) | A-70450 | CHEMBL325071
Type:
Small organic molecule
Emp. Form.:
C41H68N6O5
Mol. Mass.:
725.0158
SMILES:
CCCC[C@H](N1CCN([C@H](Cc2ccccc2)C1=O)C(=O)N1CCN(C)CC1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C[C@@H](C(C)C)C(=O)NCCC
Structure:
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