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Target
Cathepsin D
Ligand
BDBM8018
Substrate
n/a
Meas. Tech.
ChEMBL_45155 (CHEMBL657349)
IC50
320±n/a nM
Citation
 Leung, D; Abbenante, G; Fairlie, DP Protease inhibitors: current status and future prospects. J Med Chem 43:305-41 (2000) [PubMed]  Article 
Target
Name:
Cathepsin D
Synonyms:
CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:
Enzyme
Mol. Mass.:
44551.72
Organism:
Homo sapiens (Human)
Description:
Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:
412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
  
Inhibitor
Name:
BDBM8018
Synonyms:
(3S,4S)-N-butyl-3-hydroxy-6-methyl-4-[(2S,3S)-3-methyl-2-[1-(naphthalen-2-yl)acetamido]pentanamido]heptanamide | (S)-3-(S)-Hydroxy-6-methyl-4-[(S)-3-methyl-2-(2-naphthalen-2-yl-acetylamino)-pentanoylamino]-heptanoic acid butylamide | 3-Hydroxy-6-methyl-4-[3-methyl-2-(2-naphthalen-2-yl-acetylamino)-pentanoylamino]-heptanoic acid butylamide | CHEMBL115048 | hydroxyethylamine-based inhibitor 2
Type:
Small organic molecule
Emp. Form.:
C30H45N3O4
Mol. Mass.:
511.696
SMILES:
CCCCNC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)Cc1ccc2ccccc2c1)C(C)CC |r|
Structure:
Search PDB for entries with ligand similarity: