Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit rho-1
Ligand
BDBM50087271
Substrate
n/a
Meas. Tech.
ChEMBL_68580 (CHEMBL679667)
EC50
440±n/a nM
Citation
 Chebib, M; Johnston, GA GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology. J Med Chem 43:1427-47 (2000) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid receptor subunit rho-1
Synonyms:
GABA receptor rho-1 subunit | GABA-C receptor | GABRR1 | GBRR1_HUMAN
Type:
PROTEIN
Mol. Mass.:
55892.34
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456653
Residue:
479
Sequence:
MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS
  
Inhibitor
Name:
BDBM50087271
Synonyms:
(E)-4-Amino-but-2-enoic acid (TACA) | 4-Amino-but-2-enoic acid | 4-aminobut-2-enoic acid | CHEMBL33086
Type:
Small organic molecule
Emp. Form.:
C4H7NO2
Mol. Mass.:
101.1039
SMILES:
NC\C=C\C(O)=O
Structure:
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