Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit rho-2
Ligand
BDBM50087274
Substrate
n/a
Meas. Tech.
ChEMBL_68577 (CHEMBL679664)
EC50
101000±n/a nM
Citation
 Chebib, M; Johnston, GA GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology. J Med Chem 43:1427-47 (2000) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid receptor subunit rho-2
Synonyms:
GABA receptor rho-2 subunit | GABA(A) receptor subunit rho-2 | GABA(C) receptor | GABA-C receptor | GABRR2 | GBRR2_HUMAN | Gamma-aminobutyric acid receptor subunit rho-2
Type:
PROTEIN
Mol. Mass.:
54168.90
Organism:
Homo sapiens (Human)
Description:
ChEMBL_68702
Residue:
465
Sequence:
MPYFTRLILFLFCLMVLVESRKPKRKRWTGQVEMPKPSHLYKKNLDVTKIRKGKPQQLLRVDEHDFSMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASNKSMTFDGRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSHFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTVLTMTTIITGVNASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLREKFPCMCGMLHSKTMMLDGSYSESEANSLAGYPRSHILTEEERQDKIVVHLGLSGEANAARKKGLLKGQTGFRIFQNTHAIDKYSRLIFPASYIFFNLIYWSVFS
  
Inhibitor
Name:
BDBM50087274
Synonyms:
4-Amino-2-methyl-but-2-enoic acid (2-MeTACA) | 4-amino-2-methylbut-2-enoic acid | CHEMBL284115
Type:
Small organic molecule
Emp. Form.:
C5H9NO2
Mol. Mass.:
115.1305
SMILES:
C\C(=C/CN)C(O)=O
Structure:
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