Reaction Details
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Glyceraldehyde-3-phosphate dehydrogenase, cytosolic
Ligand
BDBM50369831
Substrate
n/a
Meas. Tech.
ChEMBL_72768 (CHEMBL680373)
IC50
250000±n/a nM
Citation
Bressi, JC; Verlinde, CL; Aronov, AM; Shaw, ML; Shin, SS; Nguyen, LN; Suresh, S; Buckner, FS; Van Voorhis, WC; Kuntz, ID; Hol, WG; Gelb, MH Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design. J Med Chem 44:2080-93 (2001) [PubMed] Article More Info.:
Target
Name:
Glyceraldehyde-3-phosphate dehydrogenase, cytosolic
Synonyms:
G3PC_LEIME | GAPC | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase cytosolic | Glyceraldehyde-3-phosphate dehydrogenase, cytosolic
Type:
PROTEIN
Mol. Mass.:
35645.40
Organism:
Leishmania mexicana
Description:
ChEMBL_72768
Residue:
331
Sequence:
MVKVGINGFGRIGRVVFRAAQMRPDIEIVGINDLLDAEYMAYSLKYDSTHGRFDGTVEVIKGALVVNGKSIRVTSERDPANLKWDEIGVEVVVESTGLFLTQETAHKHIEAGARRVVMTGPPKDDTPMFVMGVNHTTYKGQPIISNASCTTNCLAPLAKVVNEKYGIVEGLMTTVHATTATQKTVDGPSLKDWRGGRGASQNIIPSSTGAPKAVGKVYPALDGKLTGMAFRVPTPNVSVVDLTVRLEKPATYKDICAAIKAAAEGEMKGILGYTDDEVVSSDFNGVALTSVFDVKAGISLNDHFVKLVSWYDNETGYSHKVLDLILHTSAR
Inhibitor
Name:
BDBM50369831
Synonyms:
CHEMBL608890
Type:
Small organic molecule
Emp. Form.:
C18H26N6O4
Mol. Mass.:
390.4368
SMILES:
Nc1ncnc2n(cnc12)C1O[C@H](CNC(=O)CC2CCCCC2)[C@@H](O)[C@H]1O |r|
Structure:
