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Target
Chymotrypsin-C
Ligand
BDBM50098889
Substrate
n/a
Meas. Tech.
ChEMBL_49619 (CHEMBL660458)
Ki
451±n/a nM
Citation
 Akahoshi, F; Ashimori, A; Sakashita, H; Yoshimura, T; Eda, M; Imada, T; Nakajima, M; Mitsutomi, N; Kuwahara, S; Ohtsuka, T; Fukaya, C; Miyazaki, M; Nakamura, N Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic difluoromethylene ketones as novel inhibitors of human chymase. J Med Chem 44:1297-304 (2001) [PubMed]  Article 
Target
Name:
Chymotrypsin-C
Synonyms:
CLCR | CTRC | CTRC_HUMAN | Caldecrin | Chymotrypsin | Chymotrypsin C | Chymotrypsin-C
Type:
Enzyme
Mol. Mass.:
29487.98
Organism:
Homo sapiens (Human)
Description:
Q99895
Residue:
268
Sequence:
MLGITVLAALLACASSCGVPSFPPNLSARVVGGEDARPHSWPWQISLQYLKNDTWRHTCGGTLIASNFVLTAAHCISNTRTYRVAVGKNNLEVEDEEGSLFVGVDTIHVHKRWNALLLRNDIALIKLAEHVELSDTIQVACLPEKDSLLPKDYPCYVTGWGRLWTNGPIADKLQQGLQPVVDHATCSRIDWWGFRVKKTMVCAGGDGVISACNGDSGGPLNCQLENGSWEVFGIVSFGSRRGCNTRKKPVVYTRVSAYIDWINEKMQL
  
Inhibitor
Name:
BDBM50098889
Synonyms:
4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-acetylamino]-2,2-difluoro-3-oxo-5-phenyl-pentanoic acid pentylamide | CHEMBL24697
Type:
Small organic molecule
Emp. Form.:
C29H33F2N5O4
Mol. Mass.:
553.6002
SMILES:
CCCCCNC(=O)C(F)(F)C(=O)C(Cc1ccccc1)NC(=O)Cn1c(ncc(N)c1=O)-c1cccc(C)c1
Structure:
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