Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50113865
Substrate
n/a
Meas. Tech.
ChEMBL_49312 (CHEMBL663411)
Ki
23±n/a nM
Citation
Phillips, G; Guilford, WJ; Buckman, BO; Davey, DD; Eagen, KA; Koovakkat, S; Liang, A; McCarrick, M; Mohan, R; Ng, HP; Pinkerton, M; Subramanyam, B; Ho, E; Trinh, L; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Design, synthesis, and activity of a novel series of factor Xa inhibitors: optimization of arylamidine groups. J Med Chem 45:2484-93 (2002) [PubMed] Article
More Info.:
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
Inhibitor
Name:
BDBM50113865
Synonyms:
3-[6-(5-Carbamimidoyl-2,3-dihydroxy-phenoxy)-3,5-difluoro-4-methyl-pyridin-2-yloxy]-N,N-dimethyl-benzamide | CHEMBL82456
Type:
Small organic molecule
Emp. Form.:
C22H20F2N4O5
Mol. Mass.:
458.4148
SMILES:
CN(C)C(=O)c1cccc(Oc2nc(Oc3cc(cc(O)c3O)C(N)=N)c(F)c(C)c2F)c1