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Target
Polyunsaturated fatty acid lipoxygenase ALOX12
Ligand
BDBM50114094
Substrate
n/a
Meas. Tech.
ChEMBL_209 (CHEMBL615243)
IC50
430±n/a nM
Citation
 Whitman, S; Gezginci, M; Timmermann, BN; Holman, TR Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase. J Med Chem 45:2659-61 (2002) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid lipoxygenase ALOX12
Synonyms:
12-LOX | 12-Lipoxygenase (12-LOX) | 12LO | ALOX12 | Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, 12S-type | LOG12 | LOX12_HUMAN | Platelet 12-lipoxygenase | Platelet-type lipoxygenase 12
Type:
Protein
Mol. Mass.:
75689.18
Organism:
Homo sapiens (Human)
Description:
P18054
Residue:
663
Sequence:
MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLLQFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNALDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKAGALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPMLLRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPLVMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYHLLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVSTGGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVHLFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQHAAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRRQPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENSVTI
  
Inhibitor
Name:
BDBM50114094
Synonyms:
4-bromo-5-[(2R,3S)-4-(2-bromo-4,5-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol | CHEMBL89283
Type:
Small organic molecule
Emp. Form.:
C18H20Br2O4
Mol. Mass.:
460.157
SMILES:
C[C@@H](Cc1cc(O)c(O)cc1Br)[C@H](C)Cc1cc(O)c(O)cc1Br
Structure:
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