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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM50116428
Substrate
n/a
Meas. Tech.
ChEMBL_205193 (CHEMBL812008)
IC50
1900±n/a nM
Citation
 Picard, F; Barassin, S; Mokhtarian, A; Hartmann, RW Synthesis and evaluation of 2'-substituted 4-(4'-carboxy- or 4'-carboxymethylbenzylidene)-N-acylpiperidines: highly potent and in vivo active steroid 5alpha-reductase type 2 inhibitors. J Med Chem 45:3406-17 (2002) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
S5A1_RAT | Srd5a1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:
PROTEIN
Mol. Mass.:
29788.29
Organism:
Rattus norvegicus
Description:
ChEMBL_1441437
Residue:
259
Sequence:
MVPLMELDELCLLDMLVYLEGFMAFVSIVGLRSVGSPYGRYSPQWPGIRVPARPAWFIQELPSMAWPLYEYIRPAAARLGNLPNRVLLAMFLIHYVQRTLVFPVLIRGGKPTLLVTFVLAFLFCTFNGYVQSRYLSQFAVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGETGYKIPRGGLFEYVSAANYFGELVEWCGFALASWSLQGVVFALFTLSTLLTRAKQHHQWYHEKFEDYPKSRKILIPFVL
  
Inhibitor
Name:
BDBM50116428
Synonyms:
4-(1-Diphenylacetyl-piperidin-4-ylidenemethyl)-3-methoxy-benzoic acid | CHEMBL116621
Type:
Small organic molecule
Emp. Form.:
C28H27NO4
Mol. Mass.:
441.5183
SMILES:
[#6]-[#8]-c1cc(ccc1\[#6]=[#6]-1\[#6]-[#6]-[#7](-[#6]-[#6]-1)-[#6](=O)-[#6](-c1ccccc1)-c1ccccc1)-[#6](-[#8])=O
Structure:
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