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TargetSodium-dependent noradrenaline transporter
LigandBDBM50118268
Substrate/Competitorn/a
Meas. Tech.ChEMBL_145000
IC50 1.73±n/a nM
Citation Houlihan, WJKelly, LPankuch, JKoletar, JBrand, LJanowsky, AKopajtic, TA Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter. J Med Chem45:4097-109 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Sodium-dependent noradrenaline transporter
Name:Sodium-dependent noradrenaline transporter
Synonyms:NET | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SLC6A2 | Serotonin Transporter (SERT) | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:Multi-pass membrane protein
Mol. Mass.:69337.72
Organism:Homo sapiens (human)
Description:Competition binding assay was determined using hNET stably expressed in HEK293 cells.
Residue:617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50118268
NameBDBM50118268
Synonyms:5-(4-Chloro-phenyl)-6-methoxy-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol | CHEMBL132954
TypeSmall organic molecule
Emp. Form.C17H15ClN2O2
Mol. Mass.314.766
SMILESCOc1cccc2C3=NCCN3C(O)(c12)c1ccc(Cl)cc1 |t:7|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a