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Target
Thymidine kinase, cytosolic
Ligand
BDBM50118497
Substrate
n/a
Meas. Tech.
ChEMBL_210617 (CHEMBL811734)
IC50
11000±n/a nM
Citation
 Hernández, AI; Balzarini, J; Karlsson, A; Camarasa, MJ; Pérez-Pérez, MJ Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase. J Med Chem 45:4254-63 (2002) [PubMed]  Article 
Target
Name:
Thymidine kinase, cytosolic
Synonyms:
KITH_HUMAN | TK1
Type:
PROTEIN
Mol. Mass.:
25476.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1333884
Residue:
234
Sequence:
MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVIVAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADKYHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN
  
Inhibitor
Name:
BDBM50118497
Synonyms:
CHEMBL134449 | Heptanoic acid 3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propenyl ester
Type:
Small organic molecule
Emp. Form.:
C15H22N2O4
Mol. Mass.:
294.3462
SMILES:
CCCCCCC(=O)O\C=C/Cn1cc(C)c(=O)[nH]c1=O
Structure:
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