Reaction Details
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Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Ligand
BDBM50110681
Substrate
n/a
Meas. Tech.
ChEMBL_197991 (CHEMBL872988)
IC50
>500±n/a nM
Citation
McCluskey, A; Sim, AT; Sakoff, JA Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies. J Med Chem 45:1151-75 (2002) [PubMed] Article More Info.:
Target
Name:
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Synonyms:
PP1G_HUMAN | PPP1CC | Serine/threonine protein phosphatase PP1-gamma catalytic subunit
Type:
PROTEIN
Mol. Mass.:
36983.39
Organism:
Homo sapiens (Human)
Description:
ChEMBL_473188
Residue:
323
Sequence:
MADLDKLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAEKKKPNATRPVTPPRGMITKQAKK
Inhibitor
Name:
BDBM50110681
Synonyms:
CHEMBL430266 | Calyculin-A
Type:
Small organic molecule
Emp. Form.:
C50H81N4O15P
Mol. Mass.:
1009.1697
SMILES:
COC[C@@H]([C@H](O)[C@H](O)C(=O)NCC[C@H](C)c1nc(\C=C\C[C@@H]2O[C@]3(C[C@@H](O)[C@@H]2C)O[C@H]([C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)\C=C(/C)\C(\C)=C\C=C\C(\C)=C/C#N)OC)[C@H](OP(O)(O)=O)C3(C)C)co1)N(C)C |r|
Structure:
